Sex Differences in Thoracic Aortic Disease and Dissection: JACC Review Topic of the Week

Daniela Crousillat; Joan Briller; Niti Aggarwal; Leslie Cho; Thais Coutinho; Colleen Harrington; Eric Isselbacher; Kathryn Lindley; Maral Ouzounian; Ourania Preventza; Jyoti Sharma; Ranya Sweis; Melissa Russo; Nandita Scott; Nupoor Narula

doi:10.1016/j.jacc.2023.05.067

Sex Differences in Thoracic Aortic Disease and Dissection: JACC Review Topic of the Week

J Am Coll Cardiol. 2023 Aug 29;82(9):817-827. doi: 10.1016/j.jacc.2023.05.067.

Authors

Affiliations

¹ Division of Cardiovascular Sciences, Department of Medicine and Obstetrics and Gynecology, University of South Florida Morsani College of Medicine, Tampa, Florida, USA. Electronic address: crousillatd@usf.edu.
² Division of Cardiology, Department of Medicine, University Illinois at Chicago, Chicago, Illinois, USA.
³ Department of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota, USA.
⁴ Department of Cardiovascular Medicine, Heart, Vascular Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
⁵ Division of Cardiology, Division of Cardiac Prevention and Rehabilitation, Canadian Women's Heart Health Center, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
⁶ Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
⁷ Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
⁸ Peter Munk Cardiac Centre, Division of Cardiac Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
⁹ Department of Cardiovascular Surgery, Texas Heart Institute, Houston, Texas, USA; Cardiothoracic Surgery, University of Virginia Health, Charlottesville, Virginia, USA.
¹⁰ Piedmont Heart Institute, Department of Cardiology, Atlanta, Georgia, USA.
¹¹ Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
¹² Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Women & Infants Hospital, Providence, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
¹³ Division of Cardiology and Weill Cornell Women's Heart Program, Weill Cornell Medicine, New York, New York, USA.

PMID: 37612014
DOI: 10.1016/j.jacc.2023.05.067

Abstract

Despite its higher prevalence among men, women with thoracic aortic aneurysm and dissection (TAAD) have lower rates of treatment and surgical intervention and often have worse outcomes. A growing number of women with TAAD also desire pregnancy, which can be associated with an increased risk of aortic complications. Understanding sex-specific differences in TAAD has the potential to improve care delivery, reduce disparities in treatment, and optimize outcomes for women with TAAD.

Keywords: aneurysm; aorta; disparities; dissection; pregnancy; sex.

Publication types

Review

MeSH terms

Aorta
Aortic Diseases*
Aortic Dissection* / epidemiology
Female
Humans
Male
Pregnancy
Sex Characteristics

Substances

1,3,4,6-tetra-O-acetyl-2-azido-2-deoxyglucopyranose