Detection of blood-brain barrier disruption in brains of patients with COVID-19, but no evidence of brain penetration by SARS-CoV-2

Affiliations

• ¹ Department of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, 3320 Smith Walk, 105 Hayden Hall, Philadelphia, PA, 19104, USA.
• ² Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
• ³ Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, USA.
• ⁴ Translational Neuropathology Research Laboratory, University of Pennsylvania, Philadelphia, PA, USA.
• ⁵ Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, USA.
• ⁶ Department of Microbiology, University of Pennsylvania, Philadelphia, USA.
• ⁷ Penn Center for Research on Coronaviruses and Other Emerging Pathogens, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
• ⁸ School of Neuroscience and Psychology, University of Glasgow, Glasgow, G51 4TF, UK.
• ⁹ Department of Neuropathology, Queen Elizabeth University Hospital, Glasgow, G12 8QQ, UK.
• ¹⁰ Department of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, 3320 Smith Walk, 105 Hayden Hall, Philadelphia, PA, 19104, USA. smithdou@pennmedicine.upenn.edu.