Serial head circumference measurements should be used to classify congenital microcephaly

Chutima Sengasai; Kulkanya Chokephaibulkit; Nottasorn Plipat; Pimol Wongsiridej

doi:10.1186/s12887-023-04315-4

Serial head circumference measurements should be used to classify congenital microcephaly

BMC Pediatr. 2023 Sep 27;23(1):490. doi: 10.1186/s12887-023-04315-4.

Authors

Chutima Sengasai^#¹, Kulkanya Chokephaibulkit^{1

2}, Nottasorn Plipat², Pimol Wongsiridej^#³

Affiliations

¹ Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, 2, Wanglang Road, Bangkok-Noi District, Bangkok, 10700, Thailand.
² Siriraj Institute of Clinical Research, Faculty of Medicine Siriraj Hospital, Mahidol University, 2, Wanglang Road, Bangkok-noi District, Bangkok, 10700, Thailand.
³ Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, 2, Wanglang Road, Bangkok-Noi District, Bangkok, 10700, Thailand. pimolwong@gmail.com.

^# Contributed equally.

Abstract

Background: Measuring the maximum occipitofrontal circumference only once at birth or within 24 h after birth may lead to misclassifications of microcephaly. This study compared the head circumference (HC) of newborns at birth or within 24 h after birth to their third day of life (DOL3) as well as evaluated maternal- and infant-specific factors associated with increased HC by DOL3.

Methods: This prospective study included 1131 live births between February and May 2019 with a gestational age > 27 weeks. All newborns had their HC measured at birth or within 24 h after birth as well as on DOL3 before discharge. HC measurements were performed by trained personnel using non-elastic tape measures. The World Health Organization (WHO) and Fenton Growth Charts were used as reference ranges for interpretation of full-term and preterm neonates, respectively.

Results: Paired sample t-test analyses found a statistically significant increase in HC measured on the DOL3 compared with HCs of the same newborns at birth or within 24 h of birth. The mean HC increase was 0.17 cm (95% confidence interval [0.13, 0.21], P < 0.001). The mean ± standard deviation HC within 24 h of birth and at DOL3 were 33.58 ± 1.53 cm and 33.75 ± 1.37 cm, respectively. Thirty-two newborns had HCs less than the third percentile (< P3) at birth, 25 of which had HC ≥ P3 at DOL3. After adjusting for mode of and presentation at delivery, newborns whose mothers experienced labor pains (β = 0.31, P < 0.001) and were either symmetrically (β = 0.59, P = 0.002) or asymmetrically small-for-gestational age (SGA; β = 0.37, P = 0.03) had significantly increased HC at DOL3. On average, newborns whose mothers experienced labor pain had 0.31 cm increases in HC at DOL3. Symmetrical SGA newborns also had an average 0.59 cm increase in HC at DOL3. Parity and gestational age were not associated with changes in HC.

Conclusions: Serial HC measurements on DOL3 or before newborns' discharge is crucial to classifying congenital microcephaly.

Keywords: Head circumference; Microcephaly; Neonates; Newborn infants; Thailand.

MeSH terms

Cephalometry
Female
Gestational Age
Humans
Infant
Infant, Newborn
Infant, Small for Gestational Age
Microcephaly* / diagnosis
Pregnancy
Prospective Studies