[Italian Society of Interventional Cardiology (GISE) and Italian Society of Arterial Hypertension (SIIA) Consensus document on the role of renal denervation in the management of the difficult to treat hypertension]

G Ital Cardiol (Rome). 2023 Oct;24(10 Suppl 2):53S-63S. doi: 10.1714/4101.40995.
[Article in Italian]

Abstract

Arterial hypertension is the most prevalent cardiovascular risk factor worldwide. Despite the availability of many and effective antihypertensive medications, the prevalence of uncontrolled blood pressure (BP) remains high. As sympathetic hyperactivity has long been recognized as a major contributor to resistant hypertension, catheter-based renal denervation (RDN) has emerged as a new strategy to reduce BP. RDN aims to interrupt the activity of renal sympathetic nerves by applying radiofrequency (RF) energy, ultrasound (US) energy, or injection of alcohol in the perivascular space. The Symplicity HTN-3 trial, the largest sham-controlled trial using the first-generation RF-based RDN device, failed to significantly reduce BP. Since then, new devices and techniques have been developed and consequently many sham-controlled trials using second-generation RF or US-based RDN devices have demonstrated the BP lowering efficacy and safety of the procedure. A multidisciplinary team involving hypertension experts, interventionalists with expertise in renal interventions and anesthesiologists, plays a pivotal role from the selection of the patient candidate for the procedure to the post-procedural care. The aim of this consensus document is to summarize the current evidence about the use of RDN in difficult to treat hypertension and to propose a management strategy from the selection of the patient candidate for the procedure to the post-procedural care.

Publication types

  • English Abstract

MeSH terms

  • Antihypertensive Agents / therapeutic use
  • Blood Pressure / physiology
  • Cardiology
  • Consensus
  • Controlled Clinical Trials as Topic
  • Denervation
  • Humans
  • Hypertension* / drug therapy
  • Hypertension* / surgery
  • Italy
  • Kidney / blood supply
  • Kidney / innervation
  • Sympathectomy* / methods
  • Treatment Outcome

Substances

  • Antihypertensive Agents