In order to quantify lateral asymmetric degeneration of the hippocampus for early predicting Alzheimer's disease (AD), we develop a deep learning (DL) model to learn informative features from the hippocampal magnetic resonance imaging (MRI) data for predicting AD conversion in a time-to-event prediction modeling framework. The DL model is trained on unilateral hippocampal data with an autoencoder based regularizer, facilitating quantification of lateral asymmetry in the hippocampal prediction power of AD conversion and identification of the optimal strategy to integrate the bilateral hippocampal MRI data for predicting AD. Experimental results on MRI scans of 1307 subjects (817 for training and 490 for validation) have demonstrated that the left hippocampus can better predict AD than the right hippocampus, and an integration of the bilateral hippocampal data with the instance based DL method improved AD prediction, compared with alternative predictive modeling strategies.
Keywords: Alzheimer’s disease; asymmetry; deep learning; hippocampus; time-to-event.