Genosensor on-chip paper for point of care detection: A review of biomedical analysis and food safety application

Lelya Hilda; Maysam Salih Mutlaq; Ibrahem Waleed; Raed H Althomali; Mohammed H Mahdi; Sherzod Shukhratovich Abdullaev; Rajesh Singh; Hind Ali Nasser; Yasser Fakri Mustafa; Ahmed H R Alawadi

doi:10.1016/j.talanta.2023.125274

Genosensor on-chip paper for point of care detection: A review of biomedical analysis and food safety application

Talanta. 2024 Feb 1;268(Pt 1):125274. doi: 10.1016/j.talanta.2023.125274. Epub 2023 Oct 6.

Affiliations

¹ Department of Chemistry, Universitas Islam Negeri Syekh Ali Hasan Ahmad Addary Padangsidimpuan, Padangsidimpuan, Indonesia. Electronic address: lelya@uinsyahada.ac.id.
² Department of Radiology & Sonar Techniques, AlNoor University College, Nineveh, Iraq.
³ Medical technical college, Al-Farahidi University, Iraq.
⁴ Department of Chemistry, Prince Sattam Bin Abdulaziz University, College of Arts and Science, Wadi Al-Dawasir, 11991, Saudi Arabia.
⁵ College of pharmacy, Ahl Al Bayt University, Kerbala, Iraq.
⁶ Faculty of Chemical Engineering, New Uzbekistan University, Tashkent, Uzbekistan; Department of Chemical Engineering, Central Asian University, Tashkent, Uzbekistan; Scientific and Innovation Department, Tashkent State Pedagogical University named after Nizami, Tashkent, Uzbekistan.
⁷ Department of Electronics & Communication Engineering, Uttaranchal Institute of Technology, Uttaranchal University, Dehradun, 248007, India.
⁸ College of pharmacy, Al-Ayen University, Thi-Qar, Iraq.
⁹ Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq.
¹⁰ Building and Construction Technical Engineering Department, College of Technical Engineering, The Islamic university, Najaf, Iraq.

PMID: 37839324
DOI: 10.1016/j.talanta.2023.125274

Abstract

Over the last decade, paper-based biosensing has attracted considerable attention in numerous fields due to several advantages of them. To elaborate, using paper as a substrate of sensing approaches can be considered an affordable sensing approach owing to low cost of paper, and alongside that, the ability to operate without requiring external equipment. In many cases, cost-effective fabrication techniques such as screen printed and drop casting can be supposed as other benefits of these platforms. Despite the portability and affordability of paper-based assay, two important limitations including sensitivity and selectivity can decrease the application of these sensing approaches. Initially, decoration of paper substrate with nanomaterials (NMs) can improve the properties of paper due to high surface area and conductivity of them. Secondly, the presence of bioreceptors can provide a selective detection platform. Among different bioreceptors, deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) can play a significant role. From this perspective, paper-based biosensors can be used for the detection of various gens which related to biomedical or food safety. In this review, we attempted to summarize recent trends and applications of paper-based genosensor, along with critical arguments in terms of NMs role in signal amplification. Furthermore, the lack of paper-based genosensors in field the of biomedical and food safety will be discussed in the following.

Keywords: Biomedical; Food safety; Nanomaterials; Paper-based genosensors.

Publication types

Review

MeSH terms

Biological Assay
Biosensing Techniques* / methods
Costs and Cost Analysis
Nanostructures* / chemistry
Point-of-Care Systems