Comparison of serum from lung cancer patients and from patients with benign lung nodule using FTIR spectroscopy

Huanyu Li; Jun Wang; Xiaoyun Li; Xianhong Zhu; Shaomei Guo; Hongluan Wang; Jie Yu; Xiaoqun Ye; Fan He

doi:10.1016/j.saa.2023.123596

Comparison of serum from lung cancer patients and from patients with benign lung nodule using FTIR spectroscopy

Spectrochim Acta A Mol Biomol Spectrosc. 2024 Feb 5:306:123596. doi: 10.1016/j.saa.2023.123596. Epub 2023 Oct 31.

Authors

Huanyu Li¹, Jun Wang², Xiaoyun Li², Xianhong Zhu³, Shaomei Guo², Hongluan Wang², Jie Yu², Xiaoqun Ye⁴, Fan He⁵

Affiliations

¹ Nanchang University Jiangxi Medical College, Nanchang 330006, China; Second Department of Pulmonary and Critical Care Medicine, Jiangxi Provincial People's Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, China.
² Second Department of Pulmonary and Critical Care Medicine, Jiangxi Provincial People's Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, China.
³ Key Laboratory of Applied Organic Chemistry, Higher Institutions of Jiangxi Province, Shangrao Normal University, Shangrao 334001, China.
⁴ Department of Pulmonary and Critical Care Medicine, the Second Affiliated Hospital, Nanchang University, Nanchang 330006, China. Electronic address: 511201663@qq.com.
⁵ Neonatal Intensive Care Unit, Jiangxi Provincial Children's Hospital, Nanchang 330038, China. Electronic address: 15870659307@139.com.

PMID: 37925957
DOI: 10.1016/j.saa.2023.123596

Abstract

Lungcancer remains the leading cause of cancer related deaths in worldwide. Earlydiagnosis oflungcancer can significantly improve survival rate. However, due to its close resemblance to the malignant nodules, the possible existence of benign nodules often leads to erroneous decisions. The aim of this study was to explore whether fourier transform infrared (FTIR) spectroscopy could improve the accuracy of early diagnosis of lung cancer by distinguishing lung cancer patients' (LCP') serum from patients with benign lung nodules' (PBLN') serum. In this study, A1243+1081/A1652+1539 ratio in LCP group was increased significantly compared with that in PBLN group, indicating that the ratio could be used to distinguish the serum of LCP from that of PBLN. In addition, the ratios of A2926/A2969, A1744/A2926+2859, A2926+2859/A1652+1539 were also increased significantly in LCP group compared with that in PBLN group. These findings suggest that FTIR spectroscopy might be a potentially effective method for the early diagnosis of lung cancer.

Keywords: FTIR spectroscopy; Lung cancer; Lung nodules; Serum.

MeSH terms

Humans
Lung / pathology
Lung Neoplasms* / diagnosis
Lung Neoplasms* / pathology
Spectroscopy, Fourier Transform Infrared