Herpes Simplex Virus Hepatitis in Patients Requiring Intensive Care Unit Admission: A Retrospective, Multicenter, Observational Study

Open Forum Infect Dis. 2023 Oct 3;10(11):ofad484. doi: 10.1093/ofid/ofad484. eCollection 2023 Nov.

Abstract

The clinical features and short-term prognosis of patients admitted to the intensive care unit for herpes hepatitis are lacking. Of 33 patients admitted between 2006 and 2022, 22 were immunocompromised, 4 were pregnant women, and 23 died. Sixteen patients developed a hemophagocytic syndrome. Acyclovir was initiated a median (interquartile range) of 1 (0-3) day after admission.

Keywords: ICU; acute liver failure; acyclovir; hemophagocytic syndrome; herpes simplex virus.