Association of HIV Exposure and HIV Infection With In-hospital Mortality Among Hospitalized Infants <1 Year of Age, South Africa, 2016-2018

Nicole Wolter; Sibongile Walaza; Claire von Mollendorf; Anne von Gottberg; Stefano Tempia; Meredith L McMorrow; Jocelyn Moyes; Florette Treurnicht; Orienka Hellferscee; Malefu Moleleki; Mvuyo Makhasi; Neydis Baute; Cheryl Cohen

doi:10.1093/jpids/piad100

Association of HIV Exposure and HIV Infection With In-hospital Mortality Among Hospitalized Infants <1 Year of Age, South Africa, 2016-2018

J Pediatric Infect Dis Soc. 2023 Dec 16;12(12):646-651. doi: 10.1093/jpids/piad100.

Authors

Nicole Wolter^{1

2}, Sibongile Walaza^{1

3}, Claire von Mollendorf¹, Anne von Gottberg^{1

2}, Stefano Tempia¹, Meredith L McMorrow^{4

5}, Jocelyn Moyes^{1

3}, Florette Treurnicht^{1

2}, Orienka Hellferscee^{1

2}, Malefu Moleleki^{1

2}, Mvuyo Makhasi^{1

3}, Neydis Baute⁶, Cheryl Cohen^{1

3}

Affiliations

¹ Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.
² School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
³ School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
⁴ Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA.
⁵ Influenza Program, Centers for Disease Control and Prevention, Pretoria, South Africa.
⁶ Department of Paediatrics, Mapulaneng Hospital, Mpumalanga, South Africa.

PMID: 37952237
PMCID: PMC10838708 (available on 2024-12-16)
DOI: 10.1093/jpids/piad100

Abstract

We enrolled 1323 hospitalized infants aged <1 year in 2016-2018, and examined the association between HIV status and in-hospital mortality. After controlling for confounders, HIV-exposed uninfected infants did not have an increased risk of mortality, whereas infants living with HIV had 4 times greater risk compared with HIV-uninfected infants.

Keywords: Africa; HIV exposure; HIV infection; infants; mortality.

© The Author(s) 2023. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

MeSH terms

HIV Infections* / complications
Hospital Mortality
Humans
Infant
South Africa / epidemiology

Abstract

MeSH terms

Grants and funding