Orai1 Ca2+ channel modulators as therapeutic tools for treating cancer: Emerging evidence!

Biochem Pharmacol. 2024 Jan:219:115955. doi: 10.1016/j.bcp.2023.115955. Epub 2023 Nov 29.

Abstract

In non-excitable cells, Orai proteins represent the main channel for Store-Operated Calcium Entry (SOCE), and also mediate various store-independent Calcium Entry (SICE) pathways. Deregulation of these pathways contribute to increased tumor cell proliferation, migration, metastasis, and angiogenesis. Among Orais, Orai1 is an attractive therapeutic target explaining the development of specific modulators. Therapeutic trials using Orai1 channel inhibitors have been evaluated for treating diverse diseases such as psoriasis and acute pancreatitis, and emerging data suggest that Orai1 channel modulators may be beneficial for cancer treatment. This review discusses herein the importance of Orai1 channel modulators as potential therapeutic tools and the added value of these modulators for treating cancer.

Keywords: Calcium; Cancer; Orai1; Orai1 channel modulators; SOCE; Therapeutics.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Calcium / metabolism
  • Calcium Channels / metabolism
  • Calcium Signaling / physiology
  • Humans
  • Neoplasms* / drug therapy
  • ORAI1 Protein / metabolism
  • Pancreatitis*
  • Stromal Interaction Molecule 1 / metabolism

Substances

  • Calcium Channels
  • Calcium
  • ORAI1 Protein
  • Stromal Interaction Molecule 1