Positive correlation between lipid accumulation product index and arterial stiffness in Chinese patients with type 2 diabetes

Jing Mao; Shenglian Gan; Quan Zhou; Fang Yu; Haifeng Zhou; Huilin Lu; Jing Jin; Qin Liu; Zhiming Deng

doi:10.3389/fendo.2023.1277162

Positive correlation between lipid accumulation product index and arterial stiffness in Chinese patients with type 2 diabetes

Front Endocrinol (Lausanne). 2023 Nov 23:14:1277162. doi: 10.3389/fendo.2023.1277162. eCollection 2023.

Authors

Jing Mao^#¹, Shenglian Gan^#², Quan Zhou³, Fang Yu², Haifeng Zhou², Huilin Lu², Jing Jin², Qin Liu², Zhiming Deng²

Affiliations

¹ Department of Medicine, University of South China, Hengyang, Hunan, China.
² Department of Endocrinology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, China.
³ Department of Science and Education, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, China.

^# Contributed equally.

Abstract

Background: Many studies have confirmed that lipid accumulation products (LAP) predict arterial stiffness (AS) in hypertensive patients. But there is little research on the use of LAP in identifying early atherosclerosis in patients with type 2 diabetes mellitus (T2DM). The aim of this study was to determine the relationship between the LAP index and brachial-ankle pulse wave velocity (baPWV) in Chinese patients with T2DM.

Methods: A total of 1471 Chinese participants with T2DM, ranging in age from 18 to 80, were included in this cross-sectional study. BaPWV measurements were used to calculate the AS. A baPWV greater than the 75th percentile (1700 cm/s) was defined as indicating increased AS. The LAP index was calculated from the combination of waist circumference (WC) and triglycerides (TG).

Results: According to the quartiles of the LAP index, baPWV tended to increase after adjusting for sex and age. Multiple linear regression analysis showed that the beta coefficient (β) of baPWV increased by 31.0 cm/s for each unit of lnLAP that was increased, and the 95% confidence interval (CI) was (6.5, 55.5) cm/s. In multivariate logistic regression analyses, after fully adjusting for confounders, the risk of elevated baPWV increased with each unit increase in lnLAP, with an odds ratio (OR) of 1.3 (95% CI: 1.0, 1.8). According to the generalized additive model (GAM), we found that lnLAP was positively correlated with baPWV and baPWV elevation. The results were the same for males and females. Subgroup analyses showed that the positive correlation between lnLAP and elevated baPWV did not interact across all subgroups.

Conclusions: In Chinese patients with T2DM, LAP was strongly and positively correlated with baPWV and elevated baPWV.

Keywords: arterial stiffness; brachial-ankle pulse wave velocity; insulin resistance; lipid accumulation product; type 2 diabetes mellitus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Ankle Brachial Index
China / epidemiology
Cross-Sectional Studies
Diabetes Mellitus, Type 2*
Female
Humans
Lipid Accumulation Product*
Male
Pulse Wave Analysis
Risk Factors
Vascular Stiffness*

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by the Hunan Provincial Key Laboratory of Clinical Epidemiology (2021ZNDXLCL001) and The Science and Technology Innovation Program of Changde City. (No. [2021]67).