Increased circulation of human adenovirus in 2023: an investigation of the circulating genotypes, upper respiratory viral loads, and hospital admissions in a large academic medical center

Omar Abdullah; Amary Fall; Eili Klein; Heba H Mostafa

doi:10.1128/jcm.01237-23

Increased circulation of human adenovirus in 2023: an investigation of the circulating genotypes, upper respiratory viral loads, and hospital admissions in a large academic medical center

J Clin Microbiol. 2024 Jan 17;62(1):e0123723. doi: 10.1128/jcm.01237-23. Epub 2023 Dec 19.

Authors

Omar Abdullah¹, Amary Fall¹, Eili Klein^{2

3}, Heba H Mostafa¹

Affiliations

¹ Department of Pathology, Division of Medical Microbiology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
² Department of Emergency Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
³ Center for Disease Dynamics, Economics, and Policy, Washington, DC, USA.

Abstract

The circulation of human adenoviruses (HAdV) increased in 2023. In this manuscript, we show that HAdV-B3 was predominant in 2023 in a cohort characterized by the Johns Hopkins Hospital System. We also show that HAdV-B3 was associated with an increase in viral loads in respiratory samples and provide a correlation with the clinical presentations and outcomes.

Keywords: HAdV-B3; adenovirus; ddPCR; genotyping; respiratory infection.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Academic Medical Centers
Adenovirus Infections, Human* / diagnosis
Adenovirus Infections, Human* / epidemiology
Adenoviruses, Human* / genetics
Genotype
Hospitals
Humans
Infant
Phylogeny
Polymerase Chain Reaction
Respiratory Tract Infections* / diagnosis
Respiratory Tract Infections* / epidemiology
Viral Load

Abstract

Publication types

MeSH terms

Grants and funding