Modafinil for Severe Fatigue in Inflammatory Bowel Disease: A Prospective Case Series

Calum D Moulton; Allan H Young; Ailsa L Hart

doi:10.1016/j.cgh.2023.12.030

Modafinil for Severe Fatigue in Inflammatory Bowel Disease: A Prospective Case Series

Clin Gastroenterol Hepatol. 2024 Jan 7:S1542-3565(24)00011-9. doi: 10.1016/j.cgh.2023.12.030. Online ahead of print.

Authors

Calum D Moulton¹, Allan H Young², Ailsa L Hart³

Affiliations

¹ Centre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Psychological Medicine Unit, St Mark's Hospital, London, United Kingdom. Electronic address: calum.moulton@kcl.ac.uk.
² Centre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; National Affective Disorders Service, South London and Maudsley NHS Foundation Trust, London, United Kingdom.
³ Inflammatory Bowel Disease Unit, St Mark's Hospital, London, United Kingdom.

PMID: 38191015
DOI: 10.1016/j.cgh.2023.12.030

Abstract

Fatigue is highly prevalent in patients with IBD, affecting 72% of patients with active inflammatory bowel disease (IBD) and 47% in remission, and is associated with poor quality of life and significantly wider costs.¹ However, understanding the mechanisms of IBD fatigue remains limited, as reflected in a lack of effective treatments.¹.