FBLN5 as One Presumably Prognostic Gene Potentially Modulating Tumor Immune Microenvironment for Renal Clear Cell Carcinoma in Children and Young Adults

Ming Zhang; Feng Chen; Shaoguang Feng; Xu Liu; Zhen Wang; Nan Shen; Lingjian Meng; Dongsheng Zhu; Zhitao Zhu

doi:10.2147/PGPM.S442803

FBLN5 as One Presumably Prognostic Gene Potentially Modulating Tumor Immune Microenvironment for Renal Clear Cell Carcinoma in Children and Young Adults

Pharmgenomics Pers Med. 2024 Jan 19:17:27-40. doi: 10.2147/PGPM.S442803. eCollection 2024.

Authors

Ming Zhang^#¹, Feng Chen^#², Shaoguang Feng^#³, Xu Liu⁴, Zhen Wang⁵, Nan Shen⁶, Lingjian Meng⁷, Dongsheng Zhu¹, Zhitao Zhu⁸

Affiliations

¹ Department of Pediatric Surgery, The First People's Hospital of Lianyungang, Lianyungang, People's Republic of China.
² Department of Pediatric, Luodian Hospital, Shanghai, People's Republic of China.
³ Department of Pediatric Surgery, The Children's Hospital of Hangzhou, Hangzhou, People's Republic of China.
⁴ Department of Pediatric Surgery, The Children's Hospital of Xuzhou, Xuzhou, People's Republic of China.
⁵ Department of Pediatric, the Maternal and Child Health Hospital of Zibo, Zibo, People's Republic of China.
⁶ Department of Pediatrics, Suqian Hospital Affiliated to Xuzhou Medical University, Suqian, People's Republic of China.
⁷ Department of Pediatrics, Hospital Affiliated to Xuzhou Medical University, Xuzhou, People's Republic of China.
⁸ Department of Radiology, The Second People's Hospital of Lianyungang, Lianyungang, People's Republic of China.

^# Contributed equally.

Abstract

Objective: To investigate the role of FBLN5in renal clear cell carcinoma (KIRC), in particular on the tumor's immune microenvironment, including children and young adults.

Methods: FBLN5 expression in tumor and normal samples was explored using SangerBox, TIMER2.0, GEPIA, UALCAN, HPA databases. The Linkedomics database was used to obtain FBLN5 co-expressed genes in KIRC tissue. SangerBox was also used to estimate immune infiltration of FBLN5 in KIRC. The Kaplan-Meier plotter was used to investigate the survival effects of FBLN5 expression in the presence of immune infiltration. We then collected 48 cases from 7 hospitals over a-20 year period to calculate the impact of FBLN5 on the prognosis of children and young adults with KIRC.

Results: FBLN5 expression was significantly reduced in KIRC tissue compared to normal adjacent tissue. FBLN5 was potentially involved in the immune-related biological processes. In addition, FBLN5 expression has been linked to a number of immune checkpoints, cytokines, chemokines and chemokine receptors in KIRC. At the same time, the expression of FBLN5 affected the survival rates differently in KIRC patients with high or low levels of immune infiltration. High expression of FBLN5 in children and young adults with KIRC was associated with a favorable prognosis.

Conclusion: This study shed light on the potential of FBLN5 as a prognostic marker in children and young adults with KIRC and as an immune-related target for clinical treatment.

Keywords: FBLN5; children; immune microenvironment; kidney cancer; prognostic biomarker.

Grants and funding

This study was supported by Department of Health of Zhejiang Province (grant number 2022RC234) and Annual Scientific Project Fund of Xuzhou Children’s hospital (grant number 22040406).