Overall Survival and Response with Nivolumab and Relatlimab in Advanced Melanoma

NEJM Evid. 2023 Apr;2(4):EVIDoa2200239. doi: 10.1056/EVIDoa2200239. Epub 2023 Mar 22.

Abstract

Survival and Response with Nivolumab and RelatlimabIn this follow-up, patients with unresectable stage III or IV melanoma were randomly assigned to receive nivolumab + relatlimab or nivolumab alone. After approximately 6 months of additional follow-up, the combination's median progression-free survival was 10.2 months versus 4.6 months for monotherapy. The difference in overall survival rates was not statistically significant.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Antibodies, Monoclonal, Humanized*
  • Antineoplastic Combined Chemotherapy Protocols
  • Double-Blind Method
  • Humans
  • Ipilimumab / therapeutic use
  • Melanoma* / drug therapy
  • Nivolumab / therapeutic use
  • Skin Neoplasms* / drug therapy

Substances

  • Nivolumab
  • relatlimab
  • Ipilimumab
  • Antibodies, Monoclonal, Humanized