Severe Hyponatremia Correction, Mortality, and Central Pontine Myelinolysis

Harish Seethapathy; Sophia Zhao; Tianqi Ouyang; Christie Passos; Adviti Sarang; Pui W Cheung; Sushrut S Waikar; David J R Steele; Sahir Kalim; Andrew S Allegretti; Juan Carlos Ayus; Sagar U Nigwekar

doi:10.1056/EVIDoa2300107

Severe Hyponatremia Correction, Mortality, and Central Pontine Myelinolysis

NEJM Evid. 2023 Oct;2(10):EVIDoa2300107. doi: 10.1056/EVIDoa2300107. Epub 2023 Sep 26.

Affiliations

¹ Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston.
² Section of Nephrology, Department of Medicine, Boston University School of Medicine and Boston Medical Center, Boston.
³ Department of Nephrology and Hypertension, University of California, Irvine, CA.

PMID: 38320180
DOI: 10.1056/EVIDoa2300107

Abstract

Severe Hyponatremia Correction, Mortality, and CPMWe examined 3274 patients in the hospital with admission serum sodium of less than 120 mEq/l for the development of central pontine myelinolysis (CPM). Seven patients with CPM were identified; five developed CPM despite a sodium correction rate of less than or equal to 8 mEq/l/24 hours.

MeSH terms

Humans
Hyponatremia*
Myelinolysis, Central Pontine*
Sodium

Substances

Sodium