Evidence based noninvasive presurgical evaluation for patients with drug resistant epilepsies

Curr Opin Neurol. 2024 Apr 1;37(2):141-151. doi: 10.1097/WCO.0000000000001253. Epub 2024 Feb 14.

Abstract

Purpose of review: To review the current practices and evidence for the diagnostic accuracy and the benefits of presurgical evaluation.

Recent findings: Preoperative evaluation of patients with drug-resistant focal epilepsies and subsequent epilepsy surgery leads to a significant proportion of seizure-free patients. Even those who are not completely seizure free postoperatively often experience improved quality of life with better social integration. Systematic reviews and meta-analysis on the diagnostic accuracy are available for Video-electroencephalographic (EEG) monitoring, magnetic resonance imaging (MRI), electric and magnetic source imaging, and functional MRI for lateralization of language and memory. There are currently no evidence-based international guidelines for presurgical evaluation and epilepsy surgery.

Summary: Presurgical evaluation is a complex multidisciplinary and multiprofessional clinical pathway. We rely on limited consensus-based recommendations regarding the required staffing or methodological expertise in epilepsy centers.

Publication types

  • Review
  • Meta-Analysis

MeSH terms

  • Drug Resistant Epilepsy* / diagnostic imaging
  • Drug Resistant Epilepsy* / surgery
  • Electroencephalography / methods
  • Epilepsy* / diagnostic imaging
  • Epilepsy* / surgery
  • Humans
  • Magnetic Resonance Imaging / methods
  • Quality of Life
  • Treatment Outcome