In this journal we collected original papers and review papers in translational medicine. Translational medicine is a bio-medical field of research that translates findings discovered in the laboratory to clinical life, for example: diagnostic methods, new cutting-edge medications, high-tech tools, and novel public health policy. This research combines different fields in science using new advanced technologies to improve medical care and wellbeing. The most significant impact was accomplished by the National Institutes of Health (NIH) twenty years ago, when a National Center for Translational Research was built. One of the achievements was the opening of a genetic research center that focused on RNA, circular RNAs and interference RNA. This research discovered the importance of these RNA particles in neurological and metabolic diseases, which were found to be applicable for treatment of these diseases. In this journal, original papers and reviews will express the diversity and the capabilities of this research field that has inspired so many physicians and researchers.