Editorial: T cell specificity and cross-reactivity - implications in physiology and pathology

Daniela Latorre; Silvia Monticelli; Tomasz P Wypych; Dominik Aschenbrenner; Samuele Notarbartolo

doi:10.3389/fimmu.2024.1385415

Editorial: T cell specificity and cross-reactivity - implications in physiology and pathology

Front Immunol. 2024 Feb 28:15:1385415. doi: 10.3389/fimmu.2024.1385415. eCollection 2024.

Authors

Daniela Latorre^#¹, Silvia Monticelli^#², Tomasz P Wypych^#³, Dominik Aschenbrenner^#⁴, Samuele Notarbartolo^#⁵

Affiliations

¹ Institute of Microbiology, ETH Zurich, Zurich, Switzerland.
² Institute for Research in Biomedicine, Università della Svizzera italiana (USI), Bellinzona, Switzerland.
³ Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
⁴ Immunology Disease Area, Novartis BioMedical Research, Basel, Switzerland.
⁵ Infectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

^# Contributed equally.

No abstract available

Keywords: T cell cross-reactivity; T cell receptor (TCR); T cell repertoire; autoimmune diseases; cross-reactive T cells; evolution of T cell immunity; heterologous immunity and protection; molecular mimicry.

Publication types

Editorial
Research Support, Non-U.S. Gov't

MeSH terms

Cross Reactions
Receptors, Antigen, T-Cell*
T-Cell Antigen Receptor Specificity

Substances

Receptors, Antigen, T-Cell

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. SN is supported by a Ricerca Finalizzata Giovani Ricercatori grant from the Italian Ministry of Health (RF GR-2021-12374097). DL work on this topic is supported by the Swiss National Science Foundation PRIMA grant (PR00P3_185742), the Elevation Research Grant from the GBS/CIDP Foundation International and the Novartis Foundation for medical-biological Research. Work in the SM lab on this topic is funded by the Swiss National Science Foundation Excellence grant number 310030_205197. TW is supported by the National Science Centre, grants number 2020/39/D/NZ6/02146 and 2021/41/B/NZ6/02219.