Future Therapies of Hepatic Encephalopathy

Clin Liver Dis. 2024 May;28(2):331-344. doi: 10.1016/j.cld.2024.02.002.

Abstract

Hepatic encephalopathy, either covert or overt, affects more than half of patients with cirrhosis and has lasting effects even after portal hypertension is corrected. Unfortunately, the current therapeutic options still result in high rates of relapse and progression, in part owing to cost barriers and side effects, leading to poor adherence. This review summarizes emerging treatment options, which could take advantage of alternative disease pathways to improve future care of those with hepatic encephalopathy.

Keywords: Disease management; Experimental therapeutics; Hepatic encephalopathy; Portal hypertension.

Publication types

  • Review

MeSH terms

  • Fibrosis
  • Forecasting
  • Hepatic Encephalopathy* / drug therapy
  • Hepatic Encephalopathy* / therapy
  • Humans
  • Hypertension, Portal* / complications
  • Hypertension, Portal* / therapy
  • Liver Cirrhosis / complications