Skin and Soft Tissue Actinomycosis in Children and Adolescents

Salih Demirhan; Erika Orner; Wendy Szymczak; Philip J Lee; Margaret Aldrich

doi:10.1097/INF.0000000000004345

Skin and Soft Tissue Actinomycosis in Children and Adolescents

Pediatr Infect Dis J. 2024 Apr 2. doi: 10.1097/INF.0000000000004345. Online ahead of print.

Authors

Salih Demirhan¹, Erika Orner², Wendy Szymczak², Philip J Lee¹, Margaret Aldrich¹

Affiliations

¹ From the Division of Infectious Diseases, Department of Pediatrics, Children Hospital at Montefiore and Albert Einstein College of Medicine.
² Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx.

PMID: 38564739
DOI: 10.1097/INF.0000000000004345

Abstract

Background: Pediatric actinomycosis studies are limited to case reports or small case series. In this retrospective cohort study, we aimed to describe characteristics of skin and soft tissue actinomycosis in adolescents and children.

Methods: We conducted the study from January 2019 to December 2022, including patients aged ≤21 years with at least 1-year follow-up data. All clinical cultures obtained under sterile conditions with Actinomyces growth were included.

Results: One hundred four patients met inclusion criteria; median age 19 (interquartile range: 17-20) years, 68.3% female, 46.2% Black and 47.1% Hispanic. The median antibiotic treatment duration was 10 (7-10) days, and majority of patients received treatment with non-first-line Actinomyces antibiotics. Infectious disease consultation was requested for only 7 patients during their initial skin and soft tissue actinomycosis treatment. One-third of the patients with skin and soft tissue actinomycosis had documented recurrence within a median of 10 (interquartile range: 6-16) months of the initial episode. Monobacterial culture growth (85.7% vs. 63.8%, P = 0.02), patients with body mass index >25 (75% vs. 52.6%, P = 0.04) and patients with prior abscess in the same area (18.8% vs. 51.4%, P = 0.001) were significantly higher in patients with recurrent actinomycosis compared to the nonrecurrent group. In a univariate logistic regression model, they were found to be significantly associated with recurrence; monobacterial growth [odds ratio (OR): 3.4; 95% confidence interval (CI): 1.2-9.9], body mass index >25 (OR: 2.7; 95% CI, 1.1-7.0) and prior abscess (OR: 4.6; 95% CI: 1.9-11.2).

Conclusions: Our study results highlight the importance of considering Actinomyces species in skin and soft tissue infections, especially in recurrent ones, and risk factors for recurrence. Suboptimal antibiotic utilization, very low numbers of consultations with infectious diseases and high recurrence rate suggest that providers should be informed and updated regarding this rare but hard-to-treat infection.