Early postpartum blood pressure screening is associated with increased detection of cardiovascular risk factors in women with hypertensive disorders of pregnancy

Melissa A Daubert; Amanda Stebbins; Rachel Peragallo-Urrutia; Karen Chiswell; Matthew S Loop; Ceshae Harding; Thomas Price; Tracy Y Wang

doi:10.1016/j.ahj.2024.03.014

Early postpartum blood pressure screening is associated with increased detection of cardiovascular risk factors in women with hypertensive disorders of pregnancy

Am Heart J. 2024 Apr 4:S0002-8703(24)00076-0. doi: 10.1016/j.ahj.2024.03.014. Online ahead of print.

Authors

Melissa A Daubert¹, Amanda Stebbins², Rachel Peragallo-Urrutia³, Karen Chiswell², Matthew S Loop⁴, Ceshae Harding⁵, Thomas Price⁵, Tracy Y Wang⁶

Affiliations

¹ Duke University, Durham, NC; Duke Clinical Research Institute, Durham, NC. Electronic address: melissa.daubert@duke.edu.
² Duke Clinical Research Institute, Durham, NC.
³ University of North Carolina at Chapel Hill, Chapel Hill, NC.
⁴ Auburn University, Auburn, AL.
⁵ Duke University, Durham, NC.
⁶ Duke University, Durham, NC; Duke Clinical Research Institute, Durham, NC.

PMID: 38582139
DOI: 10.1016/j.ahj.2024.03.014

Abstract

Background: Hypertensive disorders of pregnancy (HDP), including gestational hypertension, preeclampsia, and eclampsia, are risk factors for cardiovascular (CV) disease. Guidelines recommend that women with HDP be screened for the development of hypertension (HTN) within 6-12 months postpartum. However, the extent to which this early blood pressure (BP) screening is being performed and the impact on detection of CV risk factors is unknown.

Methods: Women with HDP and without pre-existing hypertension (HTN) who had at least 6 months of clinical follow-up were categorized by postpartum BP screening status: early BP screen (6-12 months after delivery) or late BP screen (≥12 months after delivery). Multivariable logistic regression identified factors associated with early screening. Multivariable Cox proportional hazards modeling examined the association between early screening and detection of incident CV risk factors: HTN, prediabetes, diabetes mellitus type 2, or hyperlipidemia.

Results: Among 4194 women with HDP, 1172 (28%) received early BP screening. Older age, pre-existing hyperlipidemia, diabetes, sickle cell disease, hypothyroidism, gestational diabetes, and delivery during or after 2014 were independently associated with early BP screening, whereas Hispanic ethnicity was associated with late BP screening. Early BP screening was most commonly performed at a primary care visit. After a median follow-up of 3.7 years, 1012 (24%) women had at least 1 new risk factor detected. Even after adjustment for baseline risk, women receiving early BP screening had a significantly higher rate of incident CV risk factor detection than women receiving late BP screening (56% vs 28%; adj. HR 2.70, 95%CI: 2.33-3.23, P < .001).

Conclusions: Early postpartum BP screening was performed in a minority of women with HDP, but was associated with greater detection of CV risk factors. More intensive postpartum CV screening and targeted interventions are needed to optimize CV health in this high-risk population of women with HDP.

Abstract

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