Construction of resveratrol and quercetin nanoparticles based on folic acid targeted Maillard products between Jiuzao glutelin isolate and carboxymethyl chitosan: Improved stability and function

Yunsong Jiang; Mengzhen Xing; Jinyuan Sun; Xin-An Zeng; Charles Brennan; Jayani Chandrapala; Mahsa Majzoobi; Baoguo Sun

doi:10.1016/j.foodchem.2024.139296

Construction of resveratrol and quercetin nanoparticles based on folic acid targeted Maillard products between Jiuzao glutelin isolate and carboxymethyl chitosan: Improved stability and function

Food Chem. 2024 Apr 16:450:139296. doi: 10.1016/j.foodchem.2024.139296. Online ahead of print.

Authors

Yunsong Jiang¹, Mengzhen Xing², Jinyuan Sun³, Xin-An Zeng⁴, Charles Brennan⁵, Jayani Chandrapala⁵, Mahsa Majzoobi⁵, Baoguo Sun⁶

Affiliations

¹ Key Laboratory of Brewing Molecular Engineering of China Light Industry, Beijing Technology and Business University, Beijing 100048, People's Republic of China; School of Food Science and Engineering, South China University of Technology, Guangzhou, People's Republic of China; School of Science, RMIT, Melbourne, Bundoora West Campus, Plenty Road, Melbourne, VIC 3083, Australia.
² Key Laboratory of New Material Research Institute, Department of Pharmaceutical Research Institute, Shandong University of Traditional Chinese Medicine, Jinan 250355, People's Republic of China.
³ Key Laboratory of Brewing Molecular Engineering of China Light Industry, Beijing Technology and Business University, Beijing 100048, People's Republic of China. Electronic address: sunjinyuan@btbu.edu.cn.
⁴ School of Food Science and Engineering, South China University of Technology, Guangzhou, People's Republic of China.
⁵ School of Science, RMIT, Melbourne, Bundoora West Campus, Plenty Road, Melbourne, VIC 3083, Australia.
⁶ Key Laboratory of Brewing Molecular Engineering of China Light Industry, Beijing Technology and Business University, Beijing 100048, People's Republic of China.

PMID: 38636381
DOI: 10.1016/j.foodchem.2024.139296

Abstract

Advanced targeted nanoparticles (NPs) were designed to enhance the targeted delivery of resveratrol (RES) and quercetin (QUE) by utilizing carboxymethyl chitosan (CTS) and Jiuzao glutelin isolate (JGI) conjugates. Briefly, RES and QUE were encapsuled within CTS-JGI-2 (CTS/JGI, m/m, 2:1). The carrier's targeting properties were further improved through the incorporation of folic acid (FA) and polyethylenimine (PEI). Moreover, the stability against digestion was enhanced by incorporating baker yeast cell walls (BYCWs) to construct RES-QUE/FA-PEI/CTS-JGI-2/MAT/BYCW NPs. The results demonstrated that FA-PEI/CTS-JGI-2/MAT/BYCW NPs could improve cellular uptake and targeting property of RES and QUE through endocytosis of folic acid receptors (FOLRs). Additionally, RES-QUE successfully alleviated LPS- and DSS-induced inflammation by regulating NF-κB/IkBa/AP-1 and AMPK/SIRT1signaling pathways and reducing the secretion of inflammatory mediators and factors. These findings indicate FA-PEI/CTS-JGI-2/MAT/BYCW NPs hold promise as an oral drug delivery system with targeted delivery capacities for functional substances prone to instability in dietary supplements.

Keywords: Anti-inflammatory; FA-PEI/CTS-JGI-2/MAT/BYCW; FOLRs; RES-QUE; Targeting ability.