Four-year mortality and physical activity in Japanese patients with chronic obstructive pulmonary disease

Seiichi Kobayashi; Fumi Chiba; Masatsugu Ishida; Hikari Satoh; Manabu Ono; Masakazu Hanagama; Masaru Yanai

doi:10.1016/j.resinv.2024.04.009

Four-year mortality and physical activity in Japanese patients with chronic obstructive pulmonary disease

Respir Investig. 2024 Apr 20;62(4):538-540. doi: 10.1016/j.resinv.2024.04.009. Online ahead of print.

Authors

Seiichi Kobayashi¹, Fumi Chiba², Masatsugu Ishida³, Hikari Satoh³, Manabu Ono³, Masakazu Hanagama³, Masaru Yanai³

Affiliations

¹ Department of Respiratory Medicine, Japanese Red Cross Ishinomaki Hospital, 71 Nishimichishita, Hebita, Ishinomaki, 986-8522, Japan. Electronic address: skoba-thk@umin.ac.jp.
² Nursing Service, ICON Outpatient Clinic, Japanese Red Cross Ishinomaki Hospital, 71 Nishimichishita, Hebita, Ishinomaki, 986-8522, Japan.
³ Department of Respiratory Medicine, Japanese Red Cross Ishinomaki Hospital, 71 Nishimichishita, Hebita, Ishinomaki, 986-8522, Japan.

PMID: 38643535
DOI: 10.1016/j.resinv.2024.04.009

Abstract

Background: Physical activity (PA) is associated with the risk of mortality in patients with chronic obstructive pulmonary disease (COPD); however, evidence is limited to the Japanese population. This study aimed to evaluate the effects of PA on long-term mortality in Japanese patients with COPD.

Methods: We conducted a prospective observational study in a cohort of Japanese patients with COPD and assessed mortality during a 4-year follow-up period. The Cox proportional hazards model was used to evaluate the association between PA and mortality.

Results: Among 309 patients (294 men; median age, 76 years), 287 completed follow-ups while 45 died. The all-cause mortality rate was 27.5% in patients with low PA and 4.1% in those with high PA. Adjusted hazard ratios for all-cause mortality were associated with high PA.

Conclusions: Higher PA levels are associated with a better prognosis across different settings and patient characteristics, even in Japanese patients with COPD.

Keywords: Chronic obstructive pulmonary disease; Daily steps; Mortality; Physical activity.