Pop-Out Myocardial Infarction Induction in Mice

Bingyan J Wang; Hina W Chaudhry

doi:10.1007/978-1-0716-3846-0_10

Pop-Out Myocardial Infarction Induction in Mice

Methods Mol Biol. 2024:2803:137-144. doi: 10.1007/978-1-0716-3846-0_10.

Authors

Bingyan J Wang¹, Hina W Chaudhry²

Affiliations

¹ Icahn School of Medicine at Mount Sinai, Department of Cardiology, New York, NY, USA.
² Icahn School of Medicine at Mount Sinai, Department of Cardiology, New York, NY, USA. hina.chaudhry@mssm.edu.

PMID: 38676890
DOI: 10.1007/978-1-0716-3846-0_10

Abstract

Myocardial infarction (MI) in mice is a widely used surgical model in preclinical cardiac repair studies to recapitulate human cardiovascular ischemic disease. Induction of reproducible infarct size is crucial for quantitative and analytical purpose. Here we describe a quick and reliable method to induce consistent infarct size in mice in less than a minute.

Keywords: Ischemia; LAD; Myocardial infarction.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Disease Models, Animal*
Humans
Mice
Myocardial Infarction* / pathology
Myocardium / metabolism
Myocardium / pathology