Swine Model of Coronary Artery Dissection

Kyra Leonard; Spyros A Mavropoulos; Renata Mazurek; Kiyotake Ishikawa

doi:10.1007/978-1-0716-3846-0_16

Swine Model of Coronary Artery Dissection

Methods Mol Biol. 2024:2803:219-226. doi: 10.1007/978-1-0716-3846-0_16.

Authors

Kyra Leonard¹, Spyros A Mavropoulos¹, Renata Mazurek¹, Kiyotake Ishikawa²

Affiliations

¹ Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
² Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. kiyotake.ishikawa@mssm.edu.

PMID: 38676896
DOI: 10.1007/978-1-0716-3846-0_16

Abstract

Coronary artery dissection (CAD) is the intimal tearing of the coronary arterial wall and can be iatrogenic, spontaneous, or traumatic in origin. CAD is a rare but challenging condition that can cause significant hemodynamic compromise. Management strategies for CAD, such as the use of mechanical circulatory support devices, are available in the clinical setting. However, the incidence, etiology, and optimal management of CAD are not well-defined, emphasizing the need for adequate animal models in preclinical studies. Large animal models provide the human-like conditions necessary for testing and development of potential treatment strategies. In this chapter, we describe a method for the creation of a CAD swine model.

Keywords: Coronary angiography; Intima; Large animal; Pseudolumen; Spontaneous coronary artery dissection.

MeSH terms

Animals
Aortic Dissection*
Coronary Artery Disease / pathology
Coronary Vessel Anomalies
Coronary Vessels* / pathology
Disease Models, Animal*
Humans
Swine
Vascular Diseases / congenital*
Vascular Diseases / etiology
Vascular Diseases / pathology
Vascular Diseases / therapy

Supplementary concepts

Coronary Artery Dissection, Spontaneous