[Cutaneous ALK rearranged spindle cell neoplasm and S-100/CD34 co-expression: report of a case]

Zhonghua Bing Li Xue Za Zhi. 2024 May 8;53(5):498-500. doi: 10.3760/cma.j.cn112151-20231025-00304.
[Article in Chinese]

Abstract

间变性淋巴瘤激酶（ALK）融合基因是多种肿瘤重要的肿瘤驱动基因。目前有多种ALK融合伴侣基因相继被检测出来。本文报道1例少见、共表达S-100蛋白和CD34皮肤梭形细胞肿瘤并通过二代测序检测到CLIP1：：ALK融合基因的病例。通过研究其形态和免疫表型以提高对此类肿瘤的认识，避免误诊、误治。.

Publication types

  • Case Reports

MeSH terms

  • Anaplastic Lymphoma Kinase* / genetics
  • Anaplastic Lymphoma Kinase* / metabolism
  • Antigens, CD34* / metabolism
  • Gene Rearrangement
  • Humans
  • Male
  • Microtubule-Associated Proteins / genetics
  • Microtubule-Associated Proteins / metabolism
  • Oncogene Proteins, Fusion / genetics
  • Oncogene Proteins, Fusion / metabolism
  • Receptor Protein-Tyrosine Kinases / genetics
  • Receptor Protein-Tyrosine Kinases / metabolism
  • S100 Proteins* / genetics
  • S100 Proteins* / metabolism
  • Skin Neoplasms* / genetics
  • Skin Neoplasms* / metabolism
  • Skin Neoplasms* / pathology

Substances

  • Anaplastic Lymphoma Kinase
  • ALK protein, human
  • S100 Proteins
  • Antigens, CD34
  • Receptor Protein-Tyrosine Kinases
  • Oncogene Proteins, Fusion
  • Microtubule-Associated Proteins