The epidemiology of acute pancreatitis in tasmania over a 12-year period: Is this a disease of disadvantage?

Richard C Turner; Sauro Salomoni; Rachel E Neale; Amanda Neil; Savio G Barreto; Chee Y Ooi; Daniel Croagh; Jeremy S Wilson; Tony Pang; Minoti Apte

doi:10.1016/j.pan.2024.04.010

The epidemiology of acute pancreatitis in tasmania over a 12-year period: Is this a disease of disadvantage?

Pancreatology. 2024 Apr 28:S1424-3903(24)00109-1. doi: 10.1016/j.pan.2024.04.010. Online ahead of print.

Authors

Richard C Turner¹, Sauro Salomoni², Rachel E Neale³, Amanda Neil⁴, Savio G Barreto⁵, Chee Y Ooi⁶, Daniel Croagh⁷, Jeremy S Wilson⁶, Tony Pang⁸, Minoti Apte⁶

Affiliations

¹ Tasmanian School of Medicine, University of Tasmania, Hobart, Australia. Electronic address: richard.turner@utas.edu.au.
² Tasmanian School of Medicine, University of Tasmania, Hobart, Australia.
³ QIMR Berghofer Medical Research Institute and School of Public Health, University of Queensland, Brisbane, Australia.
⁴ Menzies Research Institute of Tasmania, Hobart, Australia.
⁵ College of Medicine and Public Health, Flinders University, Adelaide, Australia.
⁶ University of New South Wales, Sydney, Australia; Department of Gastroenterology, Sydney Children's Hospital, Randwick, Australia.
⁷ Monash Health/Monash University, Clayton, Australia.
⁸ University of Sydney, Sydney, Australia.

PMID: 38704341
DOI: 10.1016/j.pan.2024.04.010

Abstract

Background: The global incidence of acute pancreatitis (AP) is increasing, but little information exists about trends in Australia. This study aimed to describe incidence trends, along with clinical and socio-demographic associations, in the state of Tasmania over a recent 12-year period.

Methods: The study cohort was obtained by linking clinical and administrative datasets encompassing the whole Tasmanian population between 2007 and 2018, inclusive. Pancreatitis case definition was based on relevant ICD-10 hospitalization codes, or elevated serum lipase or amylase in pathology data. Age-standardised incidence rates were estimated, overall and stratified by sex, aetiology, and Index of Relative Socio-economic Disadvantage (IRSD).

Results: In the study period, 4905 public hospital AP episodes were identified in 3503 people. The age-standardised person-based incidence rate across the entire period was 54 per 100,000 per year. Incidence was inversely related to IRSD score; 71 per 100,000 per year in the most disadvantaged quartile compared to 32 in the least disadvantaged. Biliary AP incidence was higher than that of alcohol-related AP, although the greatest incidence was in "unspecified" cases. There was an increase in incidence for the whole cohort (average annual percent change 3.23 %), largely driven by the two most disadvantaged IRSD quartiles; the least disadvantaged quartile saw a slight overall decrease.

Conclusion: This is the first Australian study providing robust evidence that AP incidence is increasing and is at the upper limit of population-based studies worldwide. This increased incidence is greatest in socio-economically disadvantaged areas, meriting further research to develop targeted, holistic management strategies.

Keywords: Acute pancreatitis; Epidemiology; Incidence; Socio-economic status; Tasmania.