Effect of propofol and ciprofol on the euphoric reaction in patients with painless gastroscopy: A prospective randomized controlled trial

Teng Li; Jin Zhang; Zhouliang Liu; Yao Lu; Chuhao Gong; Dan Han; Ying Wu; Kailun Gao; Lei Heng; Liwei Wang; Peng Peng

doi:10.1016/j.heliyon.2024.e30378

Effect of propofol and ciprofol on the euphoric reaction in patients with painless gastroscopy: A prospective randomized controlled trial

Heliyon. 2024 Apr 25;10(9):e30378. doi: 10.1016/j.heliyon.2024.e30378. eCollection 2024 May 15.

Authors

Teng Li¹, Jin Zhang¹, Zhouliang Liu¹, Yao Lu¹, Chuhao Gong², Dan Han², Ying Wu¹, Kailun Gao¹, Lei Heng^{3

4

5}, Liwei Wang^{1

6}, Peng Peng²

Affiliations

¹ XuZhou Clinical School of Xuzhou Medical University, Xuzhou, China.
² Department of Anesthesiology, Xuzhou Renci Hospital, Xuzhou, China.
³ Department of Anesthesiology, Xuzhou Cancer Hospital, Xuzhou, China.
⁴ Department of Anesthesiology, Xuzhou New Healthy Geriatric Hospital, Xuzhou, China.
⁵ Department of Anesthesiology, the Affiliated Xuzhou Hospital of JiangSu University, Xuzhou, China.
⁶ Department of Anesthesiology, Xuzhou Central Hospital, Xuzhou, China.

Abstract

Objective: To explore the effects of propofol and ciprofol on patient euphoric reactions during sedation in patients undergoing gastroscopy and to investigate potential factors that may influence euphoric reactions in patients.

Methods: A total of 217 patients were randomly divided into two groups: the propofol group (P group, n = 109) and the ciprofol group (C group, n = 108). The patients in the P group were given 2 mg/kg propofol, and those in the C group were given 0.5 mg/kg ciprofol. The patients were assessed using the Addiction Research Center Inventory-Chinese Version (ARCI-CV) to measure euphoric reactions at three time points: preexamination, 30 min after awakening, and 1 week after examination. Anxiety, depression, and sleep status were evaluated using appropriate scales at admission and 1 week after the examination. The dream rate, sedative effects, vital sign dynamics, and adverse reactions were documented during the sedation process.

Results: After 30 min of awakening, the P group and C group showed no statistically significant differences in the mean morphine-benzedrine group (MBG) score (8.84 vs. 9.09, P > 0.05), dream rate (42.2 % vs. 40.7 %, P > 0.05), or MBG score one week after the examination (7.04 vs. 7.05, P > 0.05). The regression analysis revealed that sex, dream status, Alcohol Use Disorders Identification Test (AUDIT) score, and examination time had notable impacts on the MBG-30 min score. No statistically significant differences were observed in sedative effects, anxiety, depression, or sleep status between the two groups (P > 0.05). The incidence of injection pain and severe hypotension was significantly lower in the C group (P < 0.05), and hemodynamics and SpO₂ were more stable during sedation (P < 0.05).

Conclusion: There was no significant difference between propofol and ciprofol in terms of euphoria experienced by patients after sedation in patients undergoing gastroscopy. Ciprofol has demonstrated addictive potential similar to that of propofol, warranting careful attention to its addictive potential during clinical application.

Keywords: Addiction; Ciprofol; Euphoria; Gastroscope; Propofol.