Surgical Treatment of Multiple Large Tuberous and Tendinous Xanthoma Secondary to Familial Hypercholesterolaemia: A Case Report

Haonan Guan; Guoyou Zhang; Qiqi Li; Jie Lian; Zhaoyang Dong; Lian Zhu; Kaiyan Xiao

doi:10.2147/CCID.S445163

Surgical Treatment of Multiple Large Tuberous and Tendinous Xanthoma Secondary to Familial Hypercholesterolaemia: A Case Report

Clin Cosmet Investig Dermatol. 2024 Apr 29:17:961-966. doi: 10.2147/CCID.S445163. eCollection 2024.

Authors

Haonan Guan^#¹, Guoyou Zhang^#¹, Qiqi Li¹, Jie Lian¹, Zhaoyang Dong¹, Lian Zhu¹, Kaiyan Xiao¹

Affiliation

¹ Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.

^# Contributed equally.

Abstract

Xanthomas are well-circumscribed skin lesions that are commonly seen in patients with familial hypercholesterolemia (FH). The aim of this report is to present a rare case of multiple large tuberous and tendinous xanthomas. A 17-year-old female patient in this report presented with multiple asymptomatic and papulo-nodular masses in both sides of palms, elbows, buttocks, knees, and Achilles tendons. Surgical removal of the masses was carried out in combination with lipid-lowering therapy. A following up of 3 months showed all wounds were healing well, and no recurrence of masses was observed. Therefore, for patients with xanthomas related with familial hypercholesterolaemia, lipid-lowering therapy has reportedly reduced the size of masses, but surgical treatment may be essential for large xanthomas caused pain or limitation of daily activities.

Keywords: atorvastatin; foam cells; lipid-lowering therapy; lipoprotein; soft-tissue tumors.

Publication types

Case Reports

Grants and funding

This study was supported by Shanghai Clinical Research Center of Plastic and Reconstructive Surgery supported by Science and Technology Commission of Shanghai Municipality (Grant No. 22MC1940300).