Enhanced coagulation cascade activation and styptic effects of Zn@SiO2 nanocomposite

Marvaan M S; Debashree Banita Samal; Vijay Amirtraj J; Sreevidya Subramanian; G Devanand Venkatasubbu

doi:10.1016/j.colsurfb.2024.113927

Enhanced coagulation cascade activation and styptic effects of Zn@SiO₂ nanocomposite

Colloids Surf B Biointerfaces. 2024 Apr 25:239:113927. doi: 10.1016/j.colsurfb.2024.113927. Online ahead of print.

Authors

Marvaan M S¹, Debashree Banita Samal², Vijay Amirtraj J³, Sreevidya Subramanian³, G Devanand Venkatasubbu⁴

Affiliations

¹ Department of Nanotechnology, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, Tamilnadu, India.
² Department of Biotechnology, School of Bioengineering, College of Engineering and technology, SRM Institute of science and technology, Katankulathur, Chengalpattu, Tamilnadu, India; Apollo Specialty Hospitals, OMR, Chennai, Tamilnadu, India.
³ Apollo Specialty Hospitals, OMR, Chennai, Tamilnadu, India.
⁴ Department of Nanotechnology, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, Tamilnadu, India. Electronic address: gdevanandvenkatasubbu@gmail.com.

PMID: 38714078
DOI: 10.1016/j.colsurfb.2024.113927

Abstract

Humans often have bleeding, which exerts substantial selective pressure on the coagulation system to optimize hemostasis in a variety of situations. Uncontrolled hemorrhage due to severe trauma leads to morbidity and mortality. Although nonbiological surfaces such as silicates can activate coagulation factor XII (FXII), the presence of Zn (Zinc) in the material stimulates and activates the various steps in the coagulation cascade. This results in blood clotting. The Zn@SiO₂ nanocomposite has an excellent hemostatic property that establishes hemostasis by activating the factors responsible for the formation of a stable clot called fibrin mesh. This can be used as a hemostatic agent during surgeries and in any other trauma condition related to bleeding. Zn@SiO₂ was synthesized and characterized with XRD, FTIR and HRTEM. It is analyzed for its RBC (Red Blood Corpuscles) aggregation and Platelet adhesion ability, fibrin formation, thrombus formation and prothrombin time (PT), Activated Partial Thromboplastin Time (aPTT), D-dimer for its ability to activate the coagulation cascade to achieve stable clotting.

Keywords: Adhesion; Coagulation cascade; Fibrinogen; Hemorrhage; Hemostasis.