Practical synthesis of isoindolines yields potent colistin potentiators for multidrug-resistant Acinetobacter baumannii

Org Biomol Chem. 2024 May 22;22(20):4057-4061. doi: 10.1039/d4ob00463a.

Abstract

An efficient and practical one-pot synthesis of isoindolines from readily available starting materials was achieved under mild conditions by implementing an isoindole umpolung strategy. A variety of isoindolines were prepared with good to excellent yields. Biological screens of these identified compounds demonstrated that they are potent potentiators of colistin for multi-drug resistant Acinetobacter baumannii.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter baumannii* / drug effects
  • Anti-Bacterial Agents* / chemical synthesis
  • Anti-Bacterial Agents* / chemistry
  • Anti-Bacterial Agents* / pharmacology
  • Colistin* / chemical synthesis
  • Colistin* / chemistry
  • Colistin* / pharmacology
  • Drug Resistance, Multiple, Bacterial* / drug effects
  • Isoindoles / chemical synthesis
  • Isoindoles / chemistry
  • Isoindoles / pharmacology
  • Microbial Sensitivity Tests*
  • Molecular Structure
  • Structure-Activity Relationship