Abstract
An efficient and practical one-pot synthesis of isoindolines from readily available starting materials was achieved under mild conditions by implementing an isoindole umpolung strategy. A variety of isoindolines were prepared with good to excellent yields. Biological screens of these identified compounds demonstrated that they are potent potentiators of colistin for multi-drug resistant Acinetobacter baumannii.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acinetobacter baumannii* / drug effects
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Anti-Bacterial Agents* / chemical synthesis
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Anti-Bacterial Agents* / chemistry
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Anti-Bacterial Agents* / pharmacology
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Colistin* / chemical synthesis
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Colistin* / chemistry
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Colistin* / pharmacology
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Drug Resistance, Multiple, Bacterial* / drug effects
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Isoindoles / chemical synthesis
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Isoindoles / chemistry
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Isoindoles / pharmacology
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Microbial Sensitivity Tests*
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Molecular Structure
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Structure-Activity Relationship