Can serum NSE predict and evaluate sepsis-associated encephalopathy: A protocol for a systematic review and meta-analysis

Jiyun Hu; Shucai Xie; Ya Liao; Wei Chen; Zhaoxin Qian; Lina Zhang

doi:10.1016/j.jocn.2024.04.029

Can serum NSE predict and evaluate sepsis-associated encephalopathy: A protocol for a systematic review and meta-analysis

J Clin Neurosci. 2024 Jun:124:150-153. doi: 10.1016/j.jocn.2024.04.029. Epub 2024 May 7.

Authors

Jiyun Hu¹, Shucai Xie¹, Ya Liao¹, Wei Chen¹, Zhaoxin Qian², Lina Zhang³

Affiliations

¹ Department of Critical Care Medicine, Hunan Provincial Clinical Research Center for Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008, Hunan, PR China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China.
² Department of Critical Care Medicine, Hunan Provincial Clinical Research Center for Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008, Hunan, PR China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China. Electronic address: xyqzx@csu.edu.cn.
³ Department of Critical Care Medicine, Hunan Provincial Clinical Research Center for Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008, Hunan, PR China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China. Electronic address: zln7095@csu.edu.cn.

PMID: 38718610
DOI: 10.1016/j.jocn.2024.04.029

Abstract

Introduction: Brain dysfunction in sepsis is known as sepsis-associated encephalopathy (SAE), which often results in severe cognitive and neurological sequelae and increases the risk of death. Neuron specific enolase (NSE) may serve as an important neurocritical biomarker for detection and longitudinal monitoring in SAE patients. Our systematic review and meta-analysis will aim to explore the diagnostic and prognostic value of serum NSE in SAE patients. Currently, no systematic review and meta-analysis have been assessed that NSE as a biomarker of SAE.

Methods and analysis: We will conduct a systematic review and meta-analysis of serum NSE for the diagnostic and prognostic value of SAE patients. The primary objective is to evaluate the diagnostic accuracy of serum NSE as an independent biomarker for SAE. The secondary objective is to determine the prognostic strength of serum NSE as an independent biomarker of mortality in septic patients determine. We will perform a systematic search and descriptive review using the MEDLINE database and the PubMed interface. We will assign two independent reviewers to review all collected titles and associated abstracts, review full articles, and extract study data. We will use the Quality Assessment of Diagnostic Accuracy Studies version 2 (QUADAS-2) assessment tool according to the recommendation by the Cochrane Collaboration to evaluate quality and risk of bias of the selected studies. Subgroup and sensitivity analyses will also be used to assess heterogeneity. Review Manager version 5.4 and Stata16.0. will be used for statistical analysis.

Ethics and dissemination: The meta-analysis will provide ICU physicians with the most current information to predict which patients are at risk of SAE and take corresponding intervention measures to reduce morbidity and ameliorate neurological outcomes. There is no need for ethics approval for this review. The findings will be disseminated in a peer-reviewed journal.

Trial registration number: CRD42023398736.

Keywords: Biomarker; Meta-analysis; NSE; Outcome; Sepsis-associated encephalopathy.

Publication types

Review

MeSH terms

Biomarkers* / blood
Humans
Meta-Analysis as Topic*
Phosphopyruvate Hydratase* / blood
Prognosis
Sepsis-Associated Encephalopathy* / blood
Sepsis-Associated Encephalopathy* / diagnosis
Systematic Reviews as Topic*