Understanding osteokine biology

Mone Zaidi; Samir Zaidi; Tony Yuen

doi:10.1016/j.cmet.2024.04.008

Understanding osteokine biology

Cell Metab. 2024 May 7;36(5):888-890. doi: 10.1016/j.cmet.2024.04.008.

Authors

Mone Zaidi¹, Samir Zaidi², Tony Yuen³

Affiliations

¹ Center for Translational Medicine and Pharmacology, Departments of Medicine and Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: mone.zaidi@mssm.edu.
² Department of Genitourinary Oncology and Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
³ Center for Translational Medicine and Pharmacology, Departments of Medicine and Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

PMID: 38718755
DOI: 10.1016/j.cmet.2024.04.008

Abstract

Bone is an endocrine organ that participates in whole-body homeostasis. The biology of bone-derived osteokines, however, remains unclear. Liang et al. integrate experimental and computational methods to discover new osteokines, establish their cell of origin and target site, and study their role in aging and during mechanical stress.

MeSH terms

Aging / metabolism
Aging / physiology
Animals
Bone and Bones* / metabolism
Humans
Stress, Mechanical