Polysaccharide extracted from Sarcandra glabra residue attenuate cognitive impairment by regulating gut microbiota in diabetic mice

Meng Ye; Yameng Liu; Feng Wang; Xiyuchen Yang; Xiaobing Yang; Xiangdong Gao; Wei Liu; Juping Yu

doi:10.1016/j.ijbiomac.2024.132121

Polysaccharide extracted from Sarcandra glabra residue attenuate cognitive impairment by regulating gut microbiota in diabetic mice

Int J Biol Macromol. 2024 May 6;270(Pt 1):132121. doi: 10.1016/j.ijbiomac.2024.132121. Online ahead of print.

Authors

Meng Ye¹, Yameng Liu¹, Feng Wang², Xiyuchen Yang¹, Xiaobing Yang³, Xiangdong Gao⁴, Wei Liu⁵, Juping Yu⁶

Affiliations

¹ Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, PR China.
² Simcere Pharmaceutical Group Limited, Nanjing 210042, PR China.
³ Biology and Medicine Department, Jiangsu Industrial Technology Research Institute, Nanjing 210031, PR China.
⁴ Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: xdgao@cpu.edu.cn.
⁵ Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: liuwei@cpu.edu.cn.
⁶ Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: jp.yu@cpu.edu.cn.

PMID: 38719002
DOI: 10.1016/j.ijbiomac.2024.132121

Abstract

Diabetic encephalopathy (DE), characterized by cognitive impairment, currently lacks targeted treatment. Previous studies have shown that Sarcandra glabra extracted residue polysaccharide (SERP) exhibited hypoglycemic effects either in vitro or in streptozotocin-induced diabetes mice. However, the therapeutic effect of SERP on DE was not elucidated. This study investigated the therapeutic effect of SERP on DE and its underlying mechanism. Our results revealed that SERP regulates glucose and lipid metabolism, improves cognitive function, and exhibits diminished activity post-antibiotic intervention. Importantly, we discovered a novel mechanism by which SERP modulates the gut microbiota, specifically enriching Bacteroidales S24-7, resulting in elevated levels of butyric acid in the intestine. This regulation modulates the intestinal endocrine cell lipid metabolism level, restores damaged intestinal barriers and neural epithelial circuits, thus exhibiting cure effects. Our findings suggest that SERP could become a candidate for treating DE, potentially involving the regulation mechanism of the "microbiota-gut-brain axis". This study underscores the unique therapeutic efficacy of SERP in managing DE, offering fresh drug candidates and innovative treatment strategies for this challenging condition.

Keywords: Diabetic encephalopathy; Gut microbiota; Polysaccharide.