Determination of pulmonary vessel alteration in Chinese male smokers by quantitative computed tomography measurements: a retrospective study

Lei Jiao; Rui Shen; Meng Li; Yudong Liang; Youmin Guo; Cong Shen

doi:10.21037/qims-23-1758

Determination of pulmonary vessel alteration in Chinese male smokers by quantitative computed tomography measurements: a retrospective study

Quant Imaging Med Surg. 2024 May 1;14(5):3289-3301. doi: 10.21037/qims-23-1758. Epub 2024 Apr 12.

Authors

Lei Jiao^{1

2}, Rui Shen³, Meng Li², Yudong Liang², Youmin Guo¹, Cong Shen¹

Affiliations

¹ Department of PET/CT, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
² Department of Imaging, Weinan Central Hospital, Weinan, China.
³ Department of Gastroenterology, Xi'an Chest Hospital, Xi'an, China.

Abstract

Background: The blood volume of intraparenchymal vessels is reported to be increased in smokers. However, the blood volume can be affected by many confounders besides tobacco exposure. This study aimed to investigate the association between cigarette smoking and pulmonary blood volume after adjusting the related factors in a large cohort of Chinese males.

Methods: In this retrospective study, male participants admitted to the First Affiliated Hospital of Xi'an Jiaotong University for annual health assessment between February 2017 and February 2018 were enrolled. All subjects underwent non-contrast chest computed tomography (CT) scans, and 152 subjects underwent a review CT scan 2-3 years later. A three-dimensional approach was employed to segment the lung and intrapulmonary vessels and quantitative CT (QCT) measurements, including lung volume (LV), intrapulmonary vessel volume (IPVV), low-attenuation area <-950 Hounsfield unit (LAA-950 and LAA-950%), and mean lung density (MLD). Linear regression was used to estimate the association between IPVV and the smoking index (SI). A paired t-test was used to compare the QCT parameters between the initial and follow-up CT scans.

Results: A total of 656 male participants were enrolled and classified into three subgroups: non-smokers (n=311), current smokers (n=267), and former smokers (n=78). The IPVV of current smokers (134.62±23.96 vs. 120.76±25.52 mL) and former smokers (130.79±25.13 vs. 120.76±25.52 mL) were significantly larger than that of non-smokers (P<0.05). A higher SI was associated with greater IPVV [non-standardized coefficient: 0.167, 95% confidence interval (CI): 0.086-0.248]. For current smokers, the IPVV of the follow-up scan significantly increased compared to its baseline scan (135.49±28.60 vs. 129.73±29.75 mL, t=-2.326, P=0.02), but for the non-smokers and former smokers, the IPVV of the follow-up scan did not increase or decrease compared to the baseline scan (P>0.05).

Conclusions: Pulmonary vascular volumes detectable on non-contrast CT are associated with cigarette exposure, and smoking cessation may prevent pulmonary vasculature remodeling.

Keywords: Cigarette smoking; longitudinal cohort; non-contrast computed tomography (non-contrast CT); pulmonary vessel volume; quantitative computed tomography (QCT).