Long-term outcomes of PDT for centrally-located early lung cancers with tumor diameters > 2.0 cm

Takumi Sonokawa; Mitsunobu Ino; Satoshi Kera; Mariko Tanaka; Kento Suzuki; Yuuya Tomioka; Yuichiro Machida; Norihito Kawasaki; Jitsuo Usuda

doi:10.1016/j.pdpdt.2024.104200

Long-term outcomes of PDT for centrally-located early lung cancers with tumor diameters > 2.0 cm

Photodiagnosis Photodyn Ther. 2024 May 7:47:104200. doi: 10.1016/j.pdpdt.2024.104200. Online ahead of print.

Authors

Takumi Sonokawa¹, Mitsunobu Ino¹, Satoshi Kera¹, Mariko Tanaka¹, Kento Suzuki², Yuuya Tomioka³, Yuichiro Machida¹, Norihito Kawasaki¹, Jitsuo Usuda⁴

Affiliations

¹ Department of Thoracic Surgery, Nippon Medical School Hospital, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
² Department of Thoracic Surgery, Nippon Medical School Chiba Hokusoh Hospital, 1715 Kamagari, Inzai, Chiba 270-1694, Japan.
³ Department of Thoracic Surgery, Nippon Medical School Musashikosugi Hospital, 1-383 Kosugi-cho, Nakahara-ku, Kawasaki, Kanagawa 211-8533, Japan.
⁴ Department of Thoracic Surgery, Nippon Medical School Hospital, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan. Electronic address: jusuda@nms.ac.jp.

PMID: 38723757
DOI: 10.1016/j.pdpdt.2024.104200

Abstract

Background: Photodynamic therapy (PDT) is used for the treatment of centrally-located early lung cancers (CLELCs) and is recommended for tumors ≤ 1.0 cm in diameter. We previously reported that PDT using talaporfin sodium, second-generation photosensitizer, for tumors > 1.0 cm but ≤ 2.0 cm in diameter was able to achieve a therapeutic outcome comparable to that of tumors with a diameter of ≤ 1.0 cm. However, the effectiveness of PDT using talaporfin sodium for tumors > 2.0 cm in diameter remains unclear. We conducted a retrospective analysis of cases in which PDT was performed for flat-type CLELCs with tumor diameters of > 2.0 cm.

Methods: We retrospectively analyzed seven cases (eight lesions) with tumor diameters > 2.0 cm and no evidence of extracartilaginous invasion or lymph node metastasis.

Results: All the patients underwent multiple PDT sessions. The PDT treatment results over the study period were partial response in one case (14.3 %), stable disease (SD) in three cases (42.9 %), and progressive disease (PD) in three cases (42.9 %). At the time of writing this report, five of seven cases (71.4 %) are still undergoing treatment. The duration of SD-the time from the start of treatment until the criteria for PD were met (SD or better maintained)-ranged from 7 to 52 months (mean, 25.3 months).

Conclusions: "Maintenance PDT" for CLELCs > 2.0 cm in diameter has the potential to inhibit tumor progression in the long term while maintaining quality of life, rather than simply aiming only for a quick radical cure.

Keywords: Centrally-located early lung cancers; Photodynamic therapy (PDT); Talaporfin sodium.