Vesicle fusion and release in neurons under dynamic mechanical equilibrium

Wenhao Liu; Tianyu Gao; Na Li; Shuai Shao; Bo Liu

doi:10.1016/j.isci.2024.109793

Vesicle fusion and release in neurons under dynamic mechanical equilibrium

iScience. 2024 Apr 19;27(5):109793. doi: 10.1016/j.isci.2024.109793. eCollection 2024 May 17.

Authors

Wenhao Liu¹, Tianyu Gao¹, Na Li^{1

2}, Shuai Shao^{1

2}, Bo Liu^{1

2}

Affiliations

¹ Cancer Hospital of Dalian University of Technology, Shenyang 110042, China.
² Faculty of Medicine, Liaoning Key Lab of Integrated Circuit and Biomedical Electronic System, Dalian University of Technology, Dalian 116024, China.

Abstract

Vesicular fusion plays a pivotal role in cellular processes, involving stages like vesicle trafficking, fusion pore formation, content release, and membrane integration or separation. This dynamic process is regulated by a complex interplay of protein assemblies, osmotic forces, and membrane tension, which together maintain a mechanical equilibrium within the cell. Changes in cellular mechanics or external pressures prompt adjustments in this equilibrium, highlighting the system's adaptability. This review delves into the synergy between intracellular proteins, structural components, and external forces in facilitating vesicular fusion and release. It also explores how cells respond to mechanical stress, maintaining equilibrium and offering insights into vesicle fusion mechanisms and the development of neurological disorders.

Keywords: Biophysics; Neuroscience.

Publication types

Review