Abstract
CD44 is a ubiquitous leukocyte adhesion molecule involved in cell-cell interaction, cell adhesion, migration, homing and differentiation. CD44 can mediate the interaction between leukemic stem cells and the surrounding extracellular matrix, thereby inducing a cascade of signaling pathways to regulate their various behaviors. In this review, we focus on the impact of CD44s/CD44v as biomarkers in leukemia development and discuss the current research and prospects for CD44-related interventions in clinical application.
Keywords:
CD44; adhesion; biomarkers; clinical application; differentiation; homing; leukemia; migration.
Copyright © 2024 Wu, Tan, Li, Han, Zhang and Lin.
Publication types
-
Review
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Biomarkers, Tumor* / metabolism
-
Humans
-
Hyaluronan Receptors* / metabolism
-
Leukemia* / immunology
-
Leukemia* / metabolism
-
Leukemia* / therapy
-
Molecular Targeted Therapy
-
Neoplastic Stem Cells* / immunology
-
Neoplastic Stem Cells* / metabolism
-
Signal Transduction
Substances
-
Hyaluronan Receptors
-
Biomarkers, Tumor
-
CD44 protein, human
Grants and funding
The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by National Natural Science Foundation of China (No. 82072354), and Zhejiang Provincial Natural Science Foundation of China under Grant No. LTGD24C040008.