Nivalones CF, four new meroterpenoids from Rhododendron nivale

Lan Wang; Xi Zeng; Tao Yuan; Houzong Yao

doi:10.1016/j.fitote.2024.106017

Nivalones CF, four new meroterpenoids from Rhododendron nivale

Fitoterapia. 2024 May 11:176:106017. doi: 10.1016/j.fitote.2024.106017. Online ahead of print.

Authors

Lan Wang¹, Xi Zeng², Tao Yuan³, Houzong Yao⁴

Affiliations

¹ School of Health, Jiangxi Normal University, Nanchang 330022, China; College of Life Sciences, Jiangxi Normal University, Nanchang 330022, China.
² College of Life Sciences, Jiangxi Normal University, Nanchang 330022, China.
³ School of Health, Jiangxi Normal University, Nanchang 330022, China; College of Life Sciences, Jiangxi Normal University, Nanchang 330022, China. Electronic address: tyuan@jxnu.edu.cn.
⁴ School of Health, Jiangxi Normal University, Nanchang 330022, China. Electronic address: yaohz@jxnu.end.cn.

PMID: 38740343
DOI: 10.1016/j.fitote.2024.106017

Abstract

Four new meroterpenoids, namely nivalones CF (1-4), along with a known meroterpenoid, cannabiorcicyclolic acid (5), were isolated from the branches and leaves of Rhododendron nivale. The chemical structures of compounds 1-4 were elucidated through comprehensive spectroscopic analyses, including NMR, UV-Vis, IR, ECD spectroscopy, as well as HR-ESI-MS. The isolated compounds were evaluated for their anti-inflammatory and neuroprotective properties. The inhibitory activity of compound 5 against lipopolysaccharide (LPS)-induced nitric oxide (NO) production was initially demonstrated, showcasing an IC₅₀ value of 21.1 μM. Additionally, both compounds 2 and 5 displayed a notable effect on the viability of H₂O₂-damaged SH-SY5Y cells, indicating their significant neuroprotection effects.

Keywords: Anti-inflammatory; Meroterpenoid; Neuroprotection; Rhododendron nivale.