Resin screening and process optimization for erythritol mother liquor chromatographic separation

Haiyang Li; Xiangying Zhao; Liping Liu; Mingjing Yao; Yanlei Han; Ruiguo Li; Jianjun Liu; Jiaxiang Zhang

doi:10.1080/10826068.2024.2349936

Resin screening and process optimization for erythritol mother liquor chromatographic separation

Prep Biochem Biotechnol. 2024 May 14:1-12. doi: 10.1080/10826068.2024.2349936. Online ahead of print.

Authors

Haiyang Li^{1

2}, Xiangying Zhao^{1

2}, Liping Liu^{1

2}, Mingjing Yao^{1

2}, Yanlei Han^{1

2}, Ruiguo Li^{1

2}, Jianjun Liu^{1

2}, Jiaxiang Zhang^{1

2}

Affiliations

¹ Shandong Food Ferment Industry Research & Design Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.
² School of Food Science and Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.

PMID: 38742596
DOI: 10.1080/10826068.2024.2349936

Abstract

In order to improve the utilization value of the erythritol mother liquor, the separation and purification of the erythritol mother liquor was selected in this study. The selected chromatographic separation programme for erythritol crystallizing mother liquor is as follows: Firstly, erythritol is resolved from mannitol and arabitol with DTF-01Ca (Suqing Group) resin and then mannitol is resolved from arabitol with 99Ca/320 (Dowex) resin. At the same time, the chromatographic conditions of the DTF-01Ca (Suqing Group) and 99Ca/320 (Dowex) resins were optimized, resulting in an optimal separation temperature and mobile phase flow rate of 70 °C, 10 ml/min. On this basis, a single-column chromatographic model was used to calculate the TD model parameter ( $N$ ) and the mass transfer coefficient ( $k_{m}$ ) of the separation of erythritol mother liquor by DTF-01Ca (Suqing Group) and 99Ca/320 (Dowex) resins. The adsorption isotherms, TD model parameter ( $N$ ) and the mass transfer coefficient ( $k_{m}$ ) provides data references for the design and operation of the simulated moving beds (SMB) separation system for the industrial-scale separation of erythritol crystallizing mother liquor.

Keywords: Chromatographic separation; erythritol; mother liquor; resin.