Fresh Insights Into SLC25A26: Potential New Therapeutic Target for Cancers: A Review

Yangheng Xu; Zhisheng Hong; Sheng Yu; Ronghan Huang; Kunqi Li; Ming Li; Sisi Xie; Lvyun Zhu

doi:10.3389/or.2024.1379323

Fresh Insights Into SLC25A26: Potential New Therapeutic Target for Cancers: A Review

Oncol Rev. 2024 Apr 30:18:1379323. doi: 10.3389/or.2024.1379323. eCollection 2024.

Authors

Yangheng Xu¹, Zhisheng Hong², Sheng Yu¹, Ronghan Huang¹, Kunqi Li¹, Ming Li³, Sisi Xie³, Lvyun Zhu³

Affiliations

¹ Science and Engineering, National University of Defense Technology, Changsha, China.
² The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
³ Department of Biology and Chemistry, College of Sciences, National University of Defense Technology, Changsha, China.

Abstract

SLC25A26 is the only known human mitochondrial S-adenosylmethionine carrier encoding gene. Recent studies have shown that SLC25A26 is abnormally expressed in some cancers, such as cervical cancer, low-grade glioma, non-small cell lung cancer, and liver cancer, which suggests SLC25A26 can affect the occurrence and development of some cancers. This article in brief briefly reviewed mitochondrial S-adenosylmethionine carrier in different species and its encoding gene, focused on the association of SLC25A26 aberrant expression and some cancers as well as potential mechanisms, summarized its potential for cancer prognosis, and characteristics of mitochondrial diseases caused by SLC25A26 mutation. Finally, we provide a brief expectation that needs to be further investigated. We speculate that SLC25A26 will be a potential new therapeutic target for some cancers.

Keywords: S-adenosylmethionine carrier protein; SLC25A26; cancer; gene expression regulation; methylation.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by grants from the National Natural Science Foundation of China (32171429), the “Huxiang Young Talents Plan” Project of Hunan Province (2019RS2030), the Natural Science Foundation of Hunan Province (2022JJ30672 and 2020JJ5657), Fund for NUDT Young Innovator Awards (20190104), and Postgraduate Scientific Research Innovation Project of Hunan Province.