Whitening and antioxidant activities of Inonotus sanghuang Extract and development of primary whitening gel products

Nat Prod Res. 2024 May 16:1-7. doi: 10.1080/14786419.2024.2340754. Online ahead of print.

Abstract

Polysaccharides and flavonoids have excellent antioxidant properties and tyrosinase inhibitory effects. In this paper, the antioxidant capacity of Inonotus sanghuang extract and its inhibition kinetics on mushroom tyrosinase were investigated to determine the preparation process of Inonotus sanghuang primary whitening gel. By conducting experimental studies on the effects of water extract and alcohol extract of Inonotus sanghuang on antioxidant capacity and tyrosinase activity, their inhibitory ability and types of inhibitory effects were determined. The single factor experiment was used to determine the preparation process of Sanghuang primary whitening gel. This study has proven that the extract of Inonotus sanghuang possesses antioxidant and tyrosinase inhibitory capabilities. It also identified the preparation process for the primary whitening gel of Inonotus sanghuang, thereby providing a theoretical and experimental basis for the development of whitening products utilising Inonotus sanghuang.

Keywords: Inonotus sanghuang extract; formulation design; melanin; traditional chinese medicine whitening skincare product; tyrosinase inhibitor.