H2O2-triggered CO release based on porphyrinic covalent organic polymers for photodynamic/gas synergistic therapy

Yang Wang; Xufeng Liang; Jian An; Jia Pu; Yujia Meng; Yiqiao Bai; Wenqiang Yu; Yunhan Gao; Tingting Chen; Yong Yao

doi:10.1039/d4cc01485e

H₂O₂-triggered CO release based on porphyrinic covalent organic polymers for photodynamic/gas synergistic therapy

Chem Commun (Camb). 2024 May 30;60(45):5864-5867. doi: 10.1039/d4cc01485e.

Authors

Yang Wang¹, Xufeng Liang¹, Jian An¹, Jia Pu¹, Yujia Meng¹, Yiqiao Bai¹, Wenqiang Yu¹, Yunhan Gao¹, Tingting Chen¹, Yong Yao¹

Affiliation

¹ School of Chemistry and Chemical Engineering, Nantong University, Nantong, Jiangsu 226019, China. ywang85@ntu.edu.cn.

PMID: 38753179
DOI: 10.1039/d4cc01485e

Abstract

A novel H₂O₂-responsive carbon monoxide nanogenerator was designed by effectively encapsulating a manganese carbonyl prodrug into porphyrinic covalent organic polymers for realizing the combined CO gas and photodynamic therapy under near infrared light irradiation.