The intermittent dynamics of driven interfaces through disordered media and its subsequent depinning for large enough driving force is a common feature for a myriad of diverse systems, starting from mode-I fracture, vortex lines in superconductors, and magnetic domain walls to invading fluid in a porous medium, to name a few. In this work, we outline a framework that can give a precursory signal of the imminent depinning transition by monitoring the variations in sizes or the inequality of the intermittent responses of a system that are seen prior to the depinning point. In particular, we use measures traditionally used to quantify economic inequality, i.e., the Gini index and the Kolkata index, for the case of the unequal responses of precritical systems. The crossing point of these two indices serves as a precursor to imminent depinning. Given a scale-free size distribution of the responses, we calculate the expressions for these indices, evaluate their crossing points, and give a recipe for forecasting depinning transitions. We apply this method to the Edwards-Wilkinson, Kardar-Parisi-Zhang, and fiber bundle model interface with variable interaction strengths and quenched disorder. The results are applicable for any interface dynamics undergoing a depinning transition. The results also explain previously observed near-universal values of Gini and Kolkata indices in self-organized critical systems.