Hemodynamics of the VenusP Valve System™-an in vitro study

Huang Chen; Milad Samaee; Michael Tree; Lakshmi Dasi; Ajit Yoganathan

doi:10.3389/fmedt.2024.1376649

Hemodynamics of the VenusP Valve System™-an in vitro study

Front Med Technol. 2024 May 2:6:1376649. doi: 10.3389/fmedt.2024.1376649. eCollection 2024.

Authors

Huang Chen^{1

2}, Milad Samaee¹, Michael Tree³, Lakshmi Dasi¹, Ajit Yoganathan¹

Affiliations

¹ Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States.
² Department of Mechanical Engineering, University of Nevada, Las Vegas, NV, United States.
³ Corvid Technologies LLC, Mooresville, NC, United States.

Abstract

This study aims to evaluate the fluid dynamic characteristics of the VenusP Valve System™ under varying cardiac outputs in vitro. A thorough hemodynamic study of the valve under physiological cardiac conditions was conducted and served as an independent assessment of the performance of the valve. Flow fields downstream of the valve near the pulmonary bifurcation were quantitatively studied by two-dimensional Particle Image Velocimetry (PIV). The obtained flow field was analyzed for potential regions of flow stasis and recirculation, and elevated shear stress and turbulence. High-speed en face imaging capturing the leaflet motion provided data for leaflet kinematic modeling. The experimental conditions for PIV studies were in accordance with ISO 5840-1:2021 standard, and two valves with different lengths and different orientations were studied. Results show good hemodynamics performance for the tested valves according to ISO 5840 standard without significant regions of flow stasis. Observed shear stress values are all well below established hemolysis limits.

Keywords: Particle Image Velocimetry; Reynolds shear stress; VenusP Valve System; hemodynamics; leaflet kinematics; transcatheter pulmonary valve replacement.

Grants and funding

The authors declare that this study received funding from Venus MedTech. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication.