The aging lung: microenvironment, mechanisms, and diseases

Yanmei Wang; Xuewen Huang; Guofeng Luo; Yunying Xu; Xiqian Deng; Yumeng Lin; Zhanzhan Wang; Shuwei Zhou; Siyu Wang; Haoran Chen; Tao Tao; Lei He; Luchuan Yang; Li Yang; Yutong Chen; Zi Jin; Chengshi He; Zhongyu Han; Xiaohong Zhang

doi:10.3389/fimmu.2024.1383503

The aging lung: microenvironment, mechanisms, and diseases

Front Immunol. 2024 May 2:15:1383503. doi: 10.3389/fimmu.2024.1383503. eCollection 2024.

Authors

Yanmei Wang^#^{1

2}, Xuewen Huang^#¹, Guofeng Luo¹, Yunying Xu¹, Xiqian Deng¹, Yumeng Lin³, Zhanzhan Wang⁴, Shuwei Zhou⁵, Siyu Wang⁶, Haoran Chen¹, Tao Tao², Lei He², Luchuan Yang², Li Yang², Yutong Chen⁷, Zi Jin⁸, Chengshi He⁹, Zhongyu Han¹, Xiaohong Zhang¹⁰

Affiliations

¹ School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
² Institute of Traditional Chinese Medicine of Sichuan Academy of Chinese Medicine Sciences (Sichuan Second Hospital of T.C.M), Chengdu, China.
³ Eye School of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
⁴ Department of Respiratory and Critical Care Medicine, The First People's Hospital of Lianyungang, Lianyungang, China.
⁵ Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
⁶ Department of Gastroenterology, The First Hospital of Hunan University of Chinese Medicine, Changsha, China.
⁷ The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
⁸ Department of Anesthesiology and Pain Rehabilitation, Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.
⁹ Department of Respiratory, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
¹⁰ Department of Emergency Medicine Center, Sichuan Province People's Hospital University of Electronic Science and Technology of China, Chengdu, China.

^# Contributed equally.

Abstract

With the development of global social economy and the deepening of the aging population, diseases related to aging have received increasing attention. The pathogenesis of many respiratory diseases remains unclear, and lung aging is an independent risk factor for respiratory diseases. The aging mechanism of the lung may be involved in the occurrence and development of respiratory diseases. Aging-induced immune, oxidative stress, inflammation, and telomere changes can directly induce and promote the occurrence and development of lung aging. Meanwhile, the occurrence of lung aging also further aggravates the immune stress and inflammatory response of respiratory diseases; the two mutually affect each other and promote the development of respiratory diseases. Explaining the mechanism and treatment direction of these respiratory diseases from the perspective of lung aging will be a new idea and research field. This review summarizes the changes in pulmonary microenvironment, metabolic mechanisms, and the progression of respiratory diseases associated with aging.

Keywords: aging; immunity microenvironment; lung diseases; mechanism; therapy.

Publication types

Review

MeSH terms

Aging* / immunology
Animals
Cellular Microenvironment*
Humans
Inflammation / immunology
Lung Diseases / etiology
Lung Diseases / immunology
Lung* / immunology
Oxidative Stress*

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The work was supported by Sichuan Cadre Health Research Project Sichuan Ganyan 2022-1001 and 2023-1001, Sichuan Provincial Department of Science and Technology Scientific Research Project 2022JDZH0027, and Sichuan Provincial Department of Science and Technology Provincial Scientific Research Institute Basic Scientific Research Project 2023JDKY0028.