Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro

J Pharmacol Exp Ther. 1973 Oct;187(1):203-10.
No abstract available

MeSH terms

  • Acetaminophen* / metabolism
  • Animals
  • Caffeine / pharmacology
  • Carbon Monoxide / pharmacology
  • Carbon Radioisotopes
  • Chemical and Drug Induced Liver Injury / etiology*
  • Cobalt / pharmacology
  • Cyanides / pharmacology
  • Cytochrome P-450 Enzyme System / metabolism*
  • Fluorenes / metabolism
  • In Vitro Techniques
  • Kinetics
  • Male
  • Methylcholanthrene / pharmacology
  • Microsomes, Liver / enzymology
  • NADP / metabolism
  • Necrosis / chemically induced
  • Phenobarbital / pharmacology
  • Piperonyl Butoxide / pharmacology
  • Protein Binding
  • Rats
  • Time Factors
  • Tritium

Substances

  • Carbon Radioisotopes
  • Cyanides
  • Fluorenes
  • Tritium
  • Acetaminophen
  • Cobalt
  • Caffeine
  • NADP
  • Methylcholanthrene
  • Carbon Monoxide
  • Cytochrome P-450 Enzyme System
  • Piperonyl Butoxide
  • Phenobarbital