Abstract
Strain BALB/c mice were injected intraperitoneally with 0.5 milliliter of pristane, and 39 to 56 days later they were infected with Abelson murine leukemia virus, which is a lymphosarcomagenic variant of Moloney virus. Fifty-eight percent of the mice developed lymphosarcoma, and 28 percent developed immunoglobulin-producing plasmacytomas within 20 to 93 days (77 to 149 days after the pristane injection). Two of 57 control mice developed plasmacytomas at days 138 and 166 after a single injection of pristane; no plasmacytomas were found in mice treated with virus alone.
MeSH terms
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Alkanes*
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Animals
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Carcinogens*
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Electrophoresis, Starch Gel
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Immunoglobulin A / isolation & purification
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Immunoglobulin Fragments / isolation & purification
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Immunoglobulins / isolation & purification
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Leukemia Virus, Murine*
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Lymphoma, Non-Hodgkin / chemically induced
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Lymphoma, Non-Hodgkin / etiology
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Mice
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Mice, Inbred BALB C
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Myeloma Proteins / isolation & purification
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Plasmacytoma / chemically induced
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Plasmacytoma / etiology*
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Plasmacytoma / immunology
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Time Factors
Substances
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Alkanes
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Carcinogens
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Immunoglobulin A
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Immunoglobulin Fragments
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Immunoglobulins
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Myeloma Proteins