Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy

Clin Pharmacol Ther. 1974 Oct;16(4):676-84. doi: 10.1002/cpt1974164676.
No abstract available

MeSH terms

  • Acetaminophen* / adverse effects
  • Acetaminophen* / blood
  • Acetaminophen* / metabolism
  • Acetaminophen* / urine
  • Acetylcysteine / urine
  • Adult
  • Amobarbital / pharmacology
  • Animals
  • Chemical and Drug Induced Liver Injury / prevention & control*
  • Chromatography, Paper
  • Cysteamine / therapeutic use
  • Cytochrome P-450 Enzyme System / metabolism
  • Desipramine / pharmacology
  • Dimercaprol / urine
  • Dose-Response Relationship, Drug
  • Enzyme Induction / drug effects
  • Female
  • Glutathione / therapeutic use*
  • Humans
  • Indicators and Reagents
  • Liver / metabolism
  • Male
  • Mass Spectrometry
  • Methyltransferases / metabolism
  • Mice
  • Microsomes, Liver / enzymology
  • Phenobarbital / pharmacology
  • Protein Binding / drug effects
  • Proteins / metabolism
  • Sulfhydryl Compounds / therapeutic use
  • Time Factors
  • Tritium

Substances

  • Indicators and Reagents
  • Proteins
  • Sulfhydryl Compounds
  • Dimercaprol
  • Tritium
  • Acetaminophen
  • Cysteamine
  • Cytochrome P-450 Enzyme System
  • Methyltransferases
  • Glutathione
  • Amobarbital
  • Desipramine
  • Acetylcysteine
  • Phenobarbital